Analysis of Genome Organization Using Computational Approaches (Internship)

Overview

About the project

While it was initially thought that the organization that is accomplished by complexing DNA with histone proteins into chromatin and chromosomes constitutes mostly an inert scaffold, it is now becoming clear that the 3D organization of genomes is critical for organismal development, tissue homeostasis and reprogramming. Indeed, changes in genome architecture contribute to or are potentially causative of many diseases including degenerative, metabolic disorders and cancer. 

In consequence, insights into the architecture and regulation of 3D genome organization are expected to provide new concepts for disease diagnosis and therapy. While considerable progress has been made in the understanding of topologically associated domains (TADs) as fundamental elements of 3D genomes, very little is known about the formation, architecture and function of compartments as higher order principles of chromatin organization. Eu- and heterochromatin constitute elementary levels of genome compartmentalization and these are marked by different patterns of chromatin modifications.

 The  Analysis of Genome Organization Using Computational Approaches (Internship) project is offered at King Abdullah University Of Science and Technology (KAUST).